Feasibility study of mechanical properties of alginates for neuroscience application using finite element method

Document Type : English

Authors

1 Department of Mechanical Engineering, Najafabad Branch, Islamic Azad University, Isfahan, 8514-3131, Iran

2 Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran

3 Biotechnology Department., Falavarjan Branch, Islamic Azad University, Isfahan, Iran

4 Institute of Psychiatry, Psychiatry and Neuroscience, Kings College London, London, UK

Abstract

Alginate is a natural polysaccharide that is extracted from alga sources mainly laminaria. Alginate is readily processable for applicable three-dimensional (3D) scaffold materials such as hydrogels, microspheres, microcapsules, sponges, foams and fibers. Alginate hydrogels have been particularly attractive in wound healing, drug delivery, neuroscience and soft tissue engineering applications. As these gels retain structural similarity to the extracellular matrices (ECM) in tissues and can be manipulated to play several critical roles. The nervous system is a crucial component of the body and damages to this system, either by of injury or disease which can result in serious or potentially lethal consequences. In this research, the aim is to simulate nerve fibers in Abaqus simulation software by finite element method (FEM). Also, the use of a similar material such as alginate can be used to validate this simulation. Restoring the damaged nervous system is a great challenge due to the complex physiology system and limited regenerative capacity. Currently, most of neural tissue engineering applications are in pre-clinical study, in particular for use in the central nervous system, however collagen polymer conduits aimed at regeneration of peripheral nerves have already been successfully tested in clinical trials. In this study, due to the complexity of measuring nerve endurance, static simulation was used in Abaqus software and the results showed that paired strings are stronger than the number of individuals and the string plays a key role in the center.

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